The Cleanroom Building Process: From Concept to Compliance with Cleanetics
At Cleanetics, we understand that a cleanroom is only as effective as the process behind it. From early planning to long-term maintenance, cleanrooms require precision, discipline, and expertise at every stage. Whether supporting pharmaceuticals, biotechnology, aerospace, or advanced manufacturing, Cleanetics partners with clients to ensure cleanroom environments meet strict performance and compliance standards — before, during, and after construction.
Below is a step-by-step overview of the cleanroom building process and how Cleanetics supports cleanroom success from start to finish.
Step 1: Define Cleanroom Requirements
Every successful cleanroom begins with clear, well-defined requirements. At this stage, Cleanetics works alongside project teams to understand how the cleanroom will be used and what standards must be met.
- Key considerations include:
- Required ISO or GMP classification
- Industry-specific regulatory requirements
- Process workflows and equipment needs
- Environmental controls for temperature and humidity
- Personnel and material flow
Early involvement helps prevent costly design changes later and ensures the cleanroom can be properly maintained once operational.
Step 2: Cleanroom Design & Engineering
Cleanroom design is where performance and practicality meet. Designs must minimize contamination risk while supporting efficient workflows.
- During this phase, Cleanetics contributes insight on:
- Cleanable surface materials and finishes
- Wall, ceiling, and flooring systems
- Airflow patterns and filtration placement
- Gowning, airlocks, and material transfer zones
- Long-term cleaning and maintenance considerations
- Designing with cleanliness in mind from day one leads to better operational outcomes.
- Step 3: Site Preparation & Infrastructure
Before construction begins, the existing facility must be evaluated and prepared to support cleanroom systems.
This stage often includes:
- Structural assessments
- HVAC and utility upgrades
- Electrical and plumbing integration
- Process piping and gas line coordination
- Cleanetics ensures that preparation aligns with future cleaning protocols and contamination control requirements.
Step 4: Cleanroom Construction & Installation
Construction is performed using cleanroom-compatible materials that are smooth, non-porous, and resistant to microbial growth.
- Typical installation elements include:
- Modular panels and cleanroom ceilings
- Specialized doors and seals
- HEPA or ULPA filtration systems
- Lighting and environmental controls
Throughout construction, Cleanetics supports cleanliness standards that reduce contamination risks before the cleanroom is commissioned.
Step 5: Environmental Testing & Validation
Once construction is complete, the cleanroom must be tested and validated to confirm it meets all required specifications.
- Testing may include:
- Particle count and airflow testing
- Filter integrity testing
- Temperature and humidity verification
- Pressure differential measurements
- Validation ensures compliance and prepares the space for safe operation.
Step 6: Commissioning, Cleaning & Ongoing Maintenance
- After validation, Cleanetics plays a critical role in transitioning the cleanroom into daily use.
- Ongoing support includes:
- Initial post-construction cleanings
- Scheduled routine and deep clean services
- Environmental monitoring support
- Staff training on cleanroom cleanliness protocols
- Proper maintenance preserves cleanroom performance, extends system lifespan, and supports continued regulatory compliance.
Why Start and End with Cleanetics
A cleanroom does not begin with construction — and it does not end at validation. True cleanroom success requires a partner that understands cleanliness as a continuous process.
At Cleanetics, we support cleanroom environments:
Before construction, by advising on cleanable design choices
During construction, by maintaining contamination control standards
After commissioning, through specialized cleaning and maintenance services
By starting and ending with Cleanetics, clients ensure their cleanroom environments remain compliant, controlled, and optimized for long-term performance.